Lorenzo's Oil Page #2
- PG-13
- Year:
- 1992
- 129 min
- 2,611 Views
...we will prevent them
accumulating in the brain.
And if we could?
There's no way to reverse
neurological damage.
All we can hope for is
to slow the cascade of symptoms.
But if it's any consolation to you,
you'll be helping us...
...understand the biochemistry
of this heartless disease.
So, can we enrol Lorenzo in our trial?
I suppose so.
Good. Then I will pass you
over to our dietician...
...and meanwhile we should arrange
some genetic counselling.
Oh, Dr Nikolais, it's highly unlikely
that we will have another child.
No, but your sisters and their daughters
may all be carriers.
- We need to test them.
- Only my family? What about his?
No, no. ALD is passed
only through the mother.
But I thought you understood all this.
We knew it was inborn, but...
...we assumed that meant
a combination of our genes.
That's true in other inherited diseases...
...but ALD is only carried
on the female chromosome.
Excuse me.
Are you saying that Lorenzo
got this directly from me?
Well, in the sense that
ALD is sex-linked, yes.
It goes from mother to son.
- And how did I get it?
- The woman gets it from her mother.
And if I inherited the defect,
why don't I have the disease?
No, the woman is only
the carrier, nothing else.
But with each conception, she has
a 50-50 chance of passing on the defect.
And when that happens...
It's the cruellest kind of genetic lottery.
- Lottery?
- Yes, a clumsy word.
I use it because it's...
so arbitrary, you know.
- No one is to blame.
- Um...
If Michaela's mother had this...
...and her mother's mother...
...why was there no warning?
Well, I suppose if you went back
into the family tree, you'd...
But remember, a short time ago
this disease didn't even have a name.
Mrs Odone, you have enough
to put up with without...
You have nothing to blame yourself for.
Thank you.
It's not a good idea.
All right, so she doesn't want me. What
about Mother? She's packed and ready.
Kenise, Michaela doesn't
want anybody around.
What about Father Killian? He can come.
Hell, no. She's not even
going to Mass now.
- Deirdre, what is happening there?
- Just let it rest, OK?
No. What will they do
for Lorenzo's birthday?
- I'll call you. Bye.
- No. Deirdre!
This is wrong. More than ever
She doesn't want nobody.
She's too angry.
We cannot afford the time to be angry.
Come on, look what she's dealing with.
She does not have to deal with it alone.
She feels incredibly alone and unlucky,
like she's been singled out by God.
- Oh, Deirdre!
- Yes! Kenise is a carrier with two girls.
Me, a carrier with no kids at all, and
Mariah has a boy but she's not a carrier.
So only Michaela gets this laid on her.
- This did not happen only to Michaela.
- Sure. You got two kids already, Odone.
Mommy will make you something better:
...a big-boy fruit treat
with five different colours.
She waited all this time to have one
child. She's not gonna have another.
Francesco! Cristina!
- Ah, buongiorno.
- Oh, Francesco!
- Cristina.
- Michaela.
Ciao.
Everyone, this is Lorenzo's sister
and brother, all the way from Rome.
This does not make sense.
Lorenzo's saturated fats have risen.
We eliminate them from his diet,
and in his blood they increase.
If these very long-chain saturated fats
are destroying his mind...
...then surely we should
take him off the diet.
Mr Odone, please be patient.
Your son has been on the diet only six
weeks. Wait until the end of the trial.
Dr Nikolais, what about the other boys?
What results are you seeing in them?
As with Lorenzo, it's too early to tell.
We need the study to run
for the full six months.
That will tell you what
...that avoiding apple skins and pizza
has no effect on this brutal disease.
Now, please, Doctor, is there anyone out
there who is chasing a definitive therapy?
You judge us too hastily. The French
have tried bone-marrow transplants...
...and in Boston we're about
to try immunosuppression.
- Why haven't we heard of these before?
- The transplants were disastrous...
...and the immunosuppression
is highly experimental.
The protocol has been limited
to six boys...
...all more profoundly
afflicted than your son.
For God's sake! How afflicted
does he need to be?
It's a school, Lorenzo,
like any other school.
- And it's full of doctors?
- Yes. Some of the cleverest in America.
- What colour is that cross?
- Red.
That's right. It's red.
I'll speak to your parents for a second.
Leah's gonna take your blood pressure.
I'll be right back.
I'll just put this around your arm.
You've had this done before, haven't you?
Look, it's important you both
Cyclophosphides are no picnic.
This is chemotherapy.
We're gonna be suppressing
his immune system. It's very high-risk.
We'll need to keep him here
Now, Lorenzo is still walking,
talking and communicating.
But that could all change.
Now, knowing all this, do you
still want us to go ahead with it?
Given the alternatives, yes.
The faculty is very grateful
Ladies and gentlemen, this is Lorenzo
Odone, whom I've spoken to you about.
Now, young Mr Odone,
you need to come with me.
You are getting so big!
Now, I'm gonna put you up here
so we can all see you, OK?
Attaboy.
we observe hemianopia...
...with transient horizontal nystagmus.
are still intact...
...and, as yet, there's no optic atrophy.
early occipital-lobe involvement.
Why are all these people here?
- I beg your pardon, Lorenzo?
- Why are all these people here?
He asks why all these people are here.
Well, they're all doctors...
...and they want to learn
how to help other boys in the future.
Other boys with the boo-boo?
- Yes, darling.
- Mm-hm.
Thank you, Lorenzo.
Now, in the scanning speech,
we look for both ends of the pathology:
...centrally for the dysphasia,
and peripherally for the dysarthria.
Now, Lorenzo, would you
walk for me, please?
Attaboy.
That's right. Hold my hands.
That's right.
Two months ago there was simply motor
lag. Now note the characteristic gait.
It's due mostly to hyperreflexia, but
exacerbated by the encroaching paresis.
You're doing very well. Keep coming.
Only if you stop talking like that.
Hello, Mr Odone. Have I got that right?
- Odo-ne.
- Odo-ne? I'm sorry.
Ellard Muscatine.
I'm with the ALD Foundation.
We heard about your boy Lorenzo,
and we'd like to offer you some help.
You're a doctor?
Doctor? Heck, no. I'm a machinist from
Allequippa, PA, but I'm an ALD parent.
This is my second time around, so I know
exactly what you're going through.
My wife Loretta and I,
we run the foundation.
We organise counselling,
conduct seminars, fund research.
We have 500 member families,
not only American...
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