Fasting Page #2

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- Like everybody else, I've

gained a pound or two a year

since I was 30.

- About three years ago,

I was diagnosed with Type 2 Diabetes.

My A1C was over 14 and I

had no idea that it was

out of control the way that it was.

I knew that I'd probably had

it based on the symptoms.

So I just tried to control

it with diet, medication,

but in the end, it just

wasn't working for me,

what I was doing so I decided

it was time to switch doctors,

got a recommendation to

Dr. Julie and it kinda,

she rocked my world.

- First came upon that

study, Dr. Panda's study,

it was very easy to understand.

It's so elegantly done

that someone who's not

in high level research

could understand this paper.

- Big gnarly study with a lot of detail,

tons of charts and graphs, big words,

I'm back and worth with Wikipedia,

took like four hours to

get through that study.

- They embrace the information

because it's something new

and it is a void in most

people's knowledge base

in terms of nutrition and

diet and it does sort of

dispel this myth that you

need to eat before bedtime

or you need to have protein before bedtime

to build muscle mass.

- So on the flight back to the west coast,

I read it again for 4 hours.

It was on that flight that

I said, I gotta try this.

- So the simple experiment

that we did was we took

exactly identical set of mice --

- One group was eating ad libitum.

So they got to eat their

food throughout the day

whenever they wanted to eat it and there,

both these groups are

on a super size me diet,

like that guy from that movie.

- I started with a high fat

diet because there are 11,000

research papers published so

far where animals or humans

are given this fatty

food and this fatty food

causes different diseases

starting from diabetes, obesity,

liver damage, cancer, and IBD,

inflammatory bowel disease,

et cetera.

- The lean mouse, without a doubt,

became obese, gained weight.

The lean mouse that was on

the time restricted regime

actually stayed lean and that's really

what caught my attention.

- So even though they eat

the same amount of calories,

at the end, the time

restricted mice are lean

compared to the ad lib fed mice.

- And they could stay progressively fitter

and all they had to do

was change when they eat,

not what they eat.

- Your body needs a daily

fasting period and that

eating erratically and kind

of eating all over the day

takes away from our body's natural rhythm

to say this is when we

eat, this is when we rest,

and it's hitting a manual override button.

- We work with a circadian rhythm.

Our bodies are on a clock basically

which is aligned with the 24

hour rotation of the earth.

- The circadian rhythm

and turning on and off

of more than 10,000 genes is

the largest regulatory network

that we know that exists in human.

- Circadian rhythms in

the liver, the pancreas,

and the fat cells get

tremendously disrupted

when you eat late at night or when you eat

for more than 12 hours during the day.

- So if the liver clock

tracks when we eat,

then forget about light/dark,

what we have to be more

careful about is when we eat

and when we fast.

- And we have to stay in beat with earth

in order to be healthy.

So we really should stop

eating by 7 P.M. at the latest

because their pancreas goes to sleep.

- Just before you wake up,

somewhere around 4 A.M.,

growth hormone, adrenaline and so on,

all get pumped up.

You're basically activating

yourself for the day.

So for all those people who say oh,

you have to get up and eat

because you're not gonna have energy,

like your body has already prepared you

for everything you're gonna do.

You don't need to do it again.

- [Michael Voiceover]

And so during the day,

we need to be able to go out

and hunt and get our food

and do all those kinds of good things

so we need access to energy.

We need to be able to

metabolize energy quickly

and we need to be able to make

sugar as quickly as possible

and we also need to be able

to oxidize fats for energy.

- So at night, we can't

absorb the fat and the salt

and the sugar.

Your body just takes it and shoves it

right into a fat store.

- In the evening once

we get ready for bed,

our body switches to another

mode and the circadian rhythms

for processing energy go down

and the circadian rhythms

that help with the repair of

the body, finding cancer cells,

renewing all of the bodily systems kick in

and those are the

strongest during the night,

immune system function, et cetera.

If you eat during the night,

you disrupt all of those

mechanisms and so not only

are you predisposing yourself

to diabetes and obesity

and hypertension,

but you're also predisposing yourself

to a pro-inflammatory

condition throughout the body

which makes it easier

for cancer to take hold.

- If you're trying to repair a highway,

you have to stop the traffic.

So similarly our body cannot repair itself

if we continue to eat.

- The body makes less insulin

so for the same sugar load

that you would give

yourself during the day

that would not cause your blood

sugar to rise significantly,

for that same sugar load after

about seven or eight o'clock

at night will cause a significant

rise in your blood sugar

mimicking the effects of diabetes.

- It was a study that came

out in a neurology journal

that found if you were

giving artificial nutrition

in the hospital,

that patients did better

if you didn't give it

around the clock.

They gave the nutrition

in a shortened time frame,

they're connecting the

person back to the day cycle,

they have a better outcome.

- Just having weighed myself this morning,

two months now have

gone by and I've dropped

somewhere in the neighborhood of 29 pounds

just with Dr. Julie.

- It wasn't hard to do because it was just

a small habit change that

I had to ask them to make.

All they had to do was

apply this shortening

their total time of eating during the day.

Hi, Nina!

- Hi, Dr. Julie.

- How are you?

Good to see you.

- Good, how are you?

- Good!

Thanks for coming today.

So we're gonna go over your

bloodtest, is that right?

- Mm hmm.

- And you had them drawn already.

- Mm hmm.

- Perfect.

So when I have people come

in and they'll tell me,

"Oh well, my parents

have high blood pressure.

"So that's probably why I have it."

It's not always a genetically

inherited problem.

It's possibly a lifestyle

inherited problem

because we carry with

us the type of habits

that our parents brought us up to have

and if late night eating

and indulging slightly

on the weekends was

something that we saw them do

or that we were allowed to do growing up,

we're gonna carry that habit with us.

- And that first night was a struggle.

I remember getting off

my plane down in Burbank

and getting ready to take

an hour and a half drive

to Santa Barbara and thinking okay,

where am I gonna stop to get

something sweet for the road

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