Decoding Annie Parker Page #5

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- And one from the dad.

Right. Now, let's say

there is some sort of

hereditary

predisposition to cancer.

All that means is that

one of the genes is damaged.

I still haven't

heard from Dr. King.

I don't think

you're the only person

to write to her, Annie.

In the last five years,

the Broad Institute,

the Genome Institute

at Washington University,

and the Baylor College of

Medicine...

And I would go through

life with this one bad gene,

and everything's still okay,

because the other gene

is fine, right?

And then one of these

factors comes along, like those...

All that would mean is that they

would have to damage the other gene?

Right. And then the cell is

damaged enough that it can mutate.

Which could be cancer.

Could be. Can be.

It's, uh...

It's all too much.

Is this a doctorly hug?

I should leave.

He was a lovely man

and a friend.

See you later.

But love is like DNA.

We can't know

its predispositions.

It wasn't to be.

For me, anyway.

- Where's Dad?

- I don't know, sweetie.

Maybe he went to work early.

- Where's Dad?

- Come on. Eat your oatmeal.

Not this. Please. Come on.

I'm not gonna eat till

you tell me where Dad is.

- Eat your oatmeal.

- Where's Dad?

- Eat your oatmeal.

- I don't want to.

I said eat your

goddamn oatmeal now!

Oh, God. William!

Honey, I'm sorry.

William!

William, no.

These are Mommy's things.

William, no. Please don't.

Oh, sweetie, I'm sorry.

Come here. Come here.

Sweetie, come on. Come on.

Come on.

Hey, come on. I'm sorry.

Hey, sweetie, come on.

Come here.

God, I'm sorry.

I will never, ever

talk to you like that again.

- Okay? I'm so sorry.

- I'm sorry.

Hey, you don't need to be sorry.

They're Mommy's silly things.

Louise? Louise!

Sweetie?

Louise?

Stop!

Oh sh*t.

- Divorced?

- Yes, sweetie.

Mommy and Daddy are gonna

live in different houses,

but that doesn't mean we don't

love you very, very much.

This way,

you'll have two houses.

I don't want two houses.

I want us all together in one house.

- So does Dad.

- Please, Paul, don't do that.

What? I'm telling the truth.

- I knew this was your fault.

- No, it's not my fault, honey.

Paul?

Maybe if you didn't

spend all your time

on this DNA sh*t.

At least there's

a reason for that.

Reason? Really? What reason?

Tell me the reason.

- Because I have to know.

- Are you f***ing joking?

- Language.

- You have a high school education, Annie.

You don't know anything.

You're not gonna find out anything.

- Is that why you won't touch me?

- Oh, here we go.

Oh, so you can say...

you can say that.

but I f***ing

can't say "f***ing"?

Do you wanna tell him

the real truth?

- Tell him about Louise?

- Oh, my God.

- What about Aunt Louise?

- Nothing, William.

It's nothing.

Tell you what, Annie.

I am sorry.

I tried. I tried.

- I just couldn't.

- Get out.

- What?

- Get out.

I'll tell you what, Annie.

At least she was there for me.

I'm so sorry.

What's going on?

- Come on.

- Just listen.

These four women

have breast cancer.

What they've found are certain,

let's call them odd proteins,

that have unique configurations

in the parent gene.

Let's say these are them.

We can identify them

by their unique,

say, shape.

Now, each parent donates

a gene to the child,

and the genes get

all mixed up, right?

But look. It's not

completely arbitrary.

- We have news.

- Genetic markers.

- We can track them through their families.

- And what we can call linkage.

Do you see it?

We now know that even though

our genes get all mixed up

when we're conceived,

certain markers remain.

- Markers?

- Genetic markers.

We can track them

through the families.

It's like a signpost

on a highway.

Say you have two stretches

of road in the desert.

- And they look exactly the same.

- Right.

But if you pass signposts,

you can measure the intervals.

And you can identify

the different stretches of road.

Even if they look

exactly the same.

And if those markers

are next to something,

like the breast cancer gene,

it can be identified.

We now know that even though

our genes get all mixed up

when we're conceived,

certain markers remain.

If we can find these markers,

we're in striking distance

of finding our gene.

Yes!

Kim kept encouraging me

to go out.

I think she wanted me

to meet someone.

Is your wife gonna

join you this evening?

I, um...

I am no longer married.

Mm-hmm.

- So is your girlfriend coming later?

- Really?

That's really

none of your business.

Mm-hmm.

Hey, is your daddy's girlfriend

coming tonight?

Dad doesn't have a girlfriend.

At a peewee hockey game,

- ...I met Marshall.

- I'm sorry about my friend.

I'm Marshall.

- I'm Annie.

- Hi.

Only a Canadian girl meets a man

at a peewee hockey game.

Christmastime

is almost here again

People come from

far and near again

Isn't Christmastime

a wonderful thing?

Deck the halls

and hang the mistletoe

Kiss the ones you love

and let 'em know

Isn't Christmastime

a wonderful thing?

- Dad!

- Hiya, sport!

Hi, Paul.

Hi.

Yeah.

- How are you?

- Hi.

You look great.

Really, really happy.

- You okay?

- Yeah.

Doing all right.

Been a little sick.

So, um, Marshall.

He's a good man.

- Yeah, he is.

- Yeah.

- You okay?

- Okay.

Um, I'm gonna go

get some... some food.

Come on, sport.

Tom, you open up the betting.

All right. Okay.

Another bad hand,

but what the heck?

Fold. Fold.

Fold. Fold. Fold.

Annie. Annie.

- Hey!

- I wanted to...

I'm smiling at you,

but you can f*** off.

This is fun.

Ah.

- Good to see you guys.

- You too, man.

- I'd love to hear that conversation.

- Oh, no.

You invited them.

Yeah, but I didn't think

they'd interact.

- Merry Christmas.

- Merry Christmas.

Well, I'll be back.

- Great.

- Okay. Yeah. We're...

Is it weird?

Did it get weird?

- Merry Christmas, Marshall.

- Merry Christmas.

Here's to her.

To Annie.

Marshall.

Marshall?

I'm up here, hon.

Marshall?

I'm in here.

I, uh...

I found the key.

I thought I'd...

clean out this room.

We could use it

as a guest room or, uh...

- No, you didn't.

- ...a study.

Keep your helixes in here.

- Did Mommy wake him up?

- Yes, she did.

No. You let him out.

You let him out.

- Who?

- You...

There's no one here.

- It's just a room.

- You can't go in that room.

- You let him out.

- Honey, no.

It's just a...

Seriously, I wouldn't

believe this either,

except it happened.

Louise called me

and told me that Paul was ill.

Hey, um...

Doctor says colorectal cancer.

Hey, um...

I was looking through these,

and, uh...

thought you might

wanna see them.

You gonna be okay with William?

By yourself, I mean?

Paul...

Imagine me and you

I do

Think about you

day and night

Day and night

It's only right

to think about

the girl you love

and hold her tight

So happy together

What did you ever see in me?

I loved the careless,

boundless, wildness of you.

Then what happened?

You were boundless and careless.

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