Extraordinary Measures Page #5

STONEHILL:
Vinh, check the breakers.

VINH:
Got it.

(SWITCH CLICKING)

VINH:

No, the whole building's out.

Well, get the backup

generator going.

We...

Wait, wait, wait.

STONEHILL:
You never bothered

to buy a backup generator?

We're in the middle

of tornado country,

for Christ's sake!

Yeah, so I'm a meteorologist?

If I don't have my

refrigeration back

in 45 minutes,

I lose the whole cell line.

It was never in the budget.

We never had the money for it.

I'm sorry, sir.

Your card, it's been denied.

What?

It got maxed out. I bought

the roller bottle unit for the lab.

Sh*t, I...

Just pay me back by the end of the month,

or I lose my apartment.

Hi, here you go. Thanks.

Yes!

Yes!

DRIVER:

Sir.

Thank you.

Fiona's in Mexico this week.

They've got pyramids there.

Mmm-hmm.

She's still got lots of things to see

before she gets to Antarctica.

Yeah.

She's gonna chop up all the

penguins with an ax.

And feed their bloody remains

to the walruses.

I see.

What?

Every time you come home for the weekend,

you don't even listen to me.

Megs.

You know what,

you're right. I'm sorry.

It's just that

I've been so busy

trying to make the special medicine

for you and Patrick.

I want it pink.

You want what?

The special medicine.

I want it to be pink.

Okay. I guess I can

ask Dr. Stonehill.

Tell him dark pink,

like this.

Not light pink.

That's for babies.

Okay.

SCIENTIST:

Here you go.

Dr. Renzler, be reasonable.

The company is only 6 months old,

and we are making great progress

towards in vivo testing.

I don't know.

The way the company is burning money...

Well, we've got to get

a leg up on the competition.

You know that Zymagen has far

more spending power than we do.

So, what you're saying,

I should have invested in Zymagen.

No, what I'm saying is, is that

we've got to beat 'em to the punch.

Either that, or scare

them into buying us out.

Well, you're scaring us investors

a hell of a lot more than

you're scaring Zymagen.

You sell the company

to Zymagen,

you're in clinical trials

by the end of the fiscal year,

or we pull the plug and cut our losses.

Goodbye.

Hello?

This construct's

looking pretty good,

but we gotta get

better cleavage

between the alpha

and the beta subunits.

Well, what if we

add a furin site

like the one in

uncovering enzyme?

Why would you wanna do that?

Doesn't it have its own...

We need to talk.

I'm busy.

You're always busy.

You always wanna talk.

Yeah, we could add furin and try

and cleave it before purification.

(CLEARS THROAT)

What are you doing?

Giving you a preview...

Guys, would you

excuse us for a minute?

of what's going to happen if we

are not in clinical trials in 4 months.

Our investors will

turn out the lights.

Science takes time, Jersey.

Don't they understand?

Yeah, they do.

They can read the Wall Street Journal.

They see that Zymagen is testing

They're testing 3 'cause they don't

know what the hell they're doing.

I'm testing one 'cause it's the right one!

I know. I believe you, Bob.

Why else do you think

I put up with all your sh*t?

Look.

I want you to go toe-to-toe

with Zymagen's scientists.

Prove to them that

your enzyme is best.

I can do that.

That's the reason I've entered

into conversations with them

to buy our company.

You're telling me?

You're not asking me?

Oh, come on, Bob.

I am just being fiscally responsible.

Nobody is gonna tell me

how to run my lab!

If I can engineer a deal,

and that is a really big "if,"

you're going to

have to forgive me

for all the money

I'm gonna make you.

I don't care about money.

I'm a scientist. I care about

more important things than that.

Don't you tell me about more

important things to care about.

Do the math.

Either we sell the company

and get a huge cash infusion,

or the investors

will shut us down.

Where you going?

I'm gonna go take a crap,

if that meets with your fiscal approval.

What, they can't drive from

the airport like ordinary people?

Bob, we need to

make this happen.

They're gonna ask us

some tough questions.

Don't take 'em personally, all right?

All right?

STONEHILL:
These lab results confirm

what I've been preaching for years,

that phosphorylation is key

to enzyme absorption.

My theory works for Pompe,

and eventually it'll work for

enzyme replacement therapies

for other lysosomal

storage disorders.

Is it too complicated?

Too complicated?

The number of

variables built into

your approach

are mind-boggling.

I mean, Jesus,

if you get even one piece wrong

in the synthesis,

just one carbohydrate

ends up in the wrong position...

Well, it's gotta be done right,

like anything worth doing.

You've never actually gotten

a drug approved.

Isn't it naive to

think you can solve

these kinds of

manufacturing challenges?

(MOUTHING)

You're right, I'm a theory guy.

My head is in the clouds.

Which is why we need you.

Unless, of course,

your reputation for solving

protein-manufacturing

problems is undeserved.

(CHUCKLES)

Nice one.

I still need to hear

about profitability.

JOHN:

Certainly, certainly.

As you know, this is not a one-time

treatment. It's a lifelong therapy.

And these patients,

they are going to

generate revenue

over the span of

their lifetime that is...

But even if you

make a usable enzyme,

clearly it won't work for all patients.

So, what survival rate do we need

to achieve a robust profit?

What rate of patient death

can be defined as acceptable loss?

Acceptable loss?

I understand the question.

Because the profit margins

on this orphan drug

are so incredibly high, the...

Even with

a mortality rate of,

say, 25% over 5 years still indicates

that there is a highly lucrative

revenue source to be realized.

Gentlemen, we have a deal.

Dr. Robert Stonehill

to see Barry Renee.

GUARD:
I have a Dr. Robert Stonehill

to see Dr. Renee.

Sir, you need to be cleared.

I'm just gonna use the restroom.

You need to be cleared to do that, sir.

Just need to...

You need a security badge.

Jesus.

Well, can I have a security badge

so I can go take a pee?

Yes, sir.

He will give that to you.

Hey, Bob.

Hey, John.

You getting comfortable?

Define "comfortable."

You haven't cashed it yet?

I haven't earned it yet.

I'll cash it when we

have a usable enzyme.

Well, it sure is beautiful.

(KIDS SHOUTING)

It sure is big.

The kids love it.

Seize the day.

Okay.

(SPEAKING IN FRENCH)

I'm stuck on this call.

Just wanted to let

you know how thrilled

we are to have

you onboard, John.

It's an honor.

You remember Dr. Kent Webber.

Of course.

It's good to see you again.

Good to see you, too.

I'll let the 2 of you get into it.

I'm expecting great things.

Yes, sir.

(SPEAKING IN FRENCH)

I've got some pretty good ideas

about how to help

the flow of information

between the 4 core enzyme groups.

Whoa, John, slow down.

That's not our established procedure.

Pardon me?

The 4 core teams are essentially

in competition with each other.

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